منابع مشابه
FGF23 Producing Mesenchymal Tumor
A 40-year-old patient was referred to Clinic of Endocrinology due to hypophosphatemia causing pain, cramps, and weakness of muscles. Moreover, his bone mineral density was very low. The previous treatment with phosphorus and active vitamin D metabolites was ineffective. In lab tests the hypophosphatemia, hyperphosphaturia, and elevated FGF23 levels were found. Somatostatin receptor scintigraphy...
متن کاملDiagnostic Modalities for FGF23-Producing Tumors in Patients with Tumor-Induced Osteomalacia
Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Excessive actions of FGF23 cause several kinds of hypophosphatemic rickets/osteomalacia. Tumor-induced rickets/osteomalacia (TIO) is a paraneoplastic syndrome caused by overproduction of FGF23 from the responsible tu...
متن کاملαKlotho: FGF23 coreceptor and FGF23-regulating hormone.
Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serve...
متن کاملVector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy.
Suicide cancer gene therapy with retroviral vector-producing cells was in the way of an adjuvant to the surgical resection of recurrent glioblastoma, although any benefit appeared to be marginal. It is likely that this therapeutic approach may have better outcomes if the vectors and transgenes are delivered more efficiently to the tumor cells. We have shown previously that tumor cells engineere...
متن کاملProgesterone Producing Granulosa Cell Tumor: a Case Report
The granulosa cell tumor is the most common malignant functioning tumor of the ovary. When functional, granulosa tumor almost always are estrogenic although rare tumors are androgenic. Progesterone producing by these tumors has only been reported twice. We report a case of granulosa cell tumor in a 7 years old girl with precocious puberty who represent the first case of progesterone producing b...
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ژورنال
عنوان ژورنال: Case Reports in Endocrinology
سال: 2014
ISSN: 2090-6501,2090-651X
DOI: 10.1155/2014/492789